{"id":1777123842,"date":"2021-11-29T12:00:00","date_gmt":"2021-11-29T12:00:00","guid":{"rendered":"https:\/\/if-pan.krakow.pl\/?p=601"},"modified":"2026-04-21T20:19:05","modified_gmt":"2026-04-21T19:19:05","slug":"dwa-nowe-projekty-opus-21","status":"publish","type":"post","link":"https:\/\/if-pan.edu.pl\/en\/aktualnosci\/archiwum\/dwa-nowe-projekty-opus-21\/","title":{"rendered":"Dwa nowe projekty OPUS 21"},"content":{"rendered":"
\n<\/div>\n

Z przyjemno\u015bci\u0105 informujemy, \u017ce dwa projekty, w\u00a0kt\u00f3rych bierze udzia\u0142 dr hab. Bernadeta Szewczyk zostan\u0105
\nsfinansowane w\u00a0programie OPUS 21<\/b>; jeden wraz z\u00a0 prof. dr hab. Jakubem
\nW\u0142odarczykiem z\u00a0Instytutu
\nBiologii Do\u015bwiadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk pt. “Molekularne mechanizmy rezyliencji zale\u017cne od
\nreceptora 5-HT7R w\u00a0chorobach zwi\u0105zanych ze\u00a0stresem”<\/i> oraz drugi wraz z\u00a0prof.
\ndr hab. Piotrem Wlaziem z\u00a0Uniwersytetu Marii Curie-Sk\u0142odowskiej w\u00a0Lublinie pt. “Wp\u0142yw SSR 504734, selektywnego inhibitora transportera
\nglicyny typu 1, na aktywno\u015b\u0107 drgawkow\u0105 i\u00a0potencja\u0142 terapeutyczny wybranych
\nlek\u00f3w przeciwdrgawkowych”. <\/i><\/p>\n

Pierwszy projekt skupia si\u0119 na wyja\u015bnieniu powi\u0105za\u0144 pomi\u0119dzy sygnalizacj\u0105 serotoninergiczn\u0105 zwi\u0105zan\u0105 z\u00a0receptorem serotoninowym 5-HT7, zmianami kszta\u0142tu kolc\u00f3w dendrytycznych oraz odporno\u015bci\u0105 na stres. G\u0142\u00f3wnym celem projektu b\u0119dzie wgl\u0105d w\u00a0biologiczn\u0105 istot\u0119 odporno\u015bci na stres otwieraj\u0105c tym samym nowy kierunek bada\u0144 w\u00a0farmakologii, gdzie nowo zaprojektowane leki przeciwdepresyjne b\u0119d\u0105 wzmacnia\u0142y mechanizmy kompensacyjne kom\u00f3rek nerwowych, bez konieczno\u015bci odwracania stanu depresyjnego, jak jest to powszechnie praktykowane. Okre\u015blenie molekularnych podstaw zwi\u0105zanych z\u00a0behawioraln\u0105 odporno\u015bci\u0105 na stres mo\u017ce r\u00f3wnie\u017c utorowa\u0107 drog\u0119 do opracowania nowych, skuteczniej dzia\u0142aj\u0105cych lek\u00f3w przeciwdepresyjnych.<\/p>\n

\n

Celem drugiego projektu jest lepsze poznanie roli transportera glicyny typu 1 (GlyT1) w\u00a0patomechanizmie padaczki poprzez zbadanie wp\u0142ywu wysoce selektywnego inhibitora GlyT1 (SSR 504734) na aktywno\u015b\u0107 drgawkow\u0105 i\u00a0skuteczno\u015b\u0107 terapeutyczn\u0105 lek\u00f3w przeciwdrgawkowych u myszy. Uzyskane wyniki pozwol\u0105 odpowiedzie\u0107 na pytanie, czy hamowanie GlyT1 mo\u017ce stanowi\u0107 racjonalny cel terapeutyczny w\u00a0leczeniu padaczki i\/lub hamowaniu procesu epileptogenezy, a\u00a0tak\u017ce czy inhibitory GlyT1 mog\u0105 wp\u0142ywa\u0107 na potencja\u0142 terapeutyczny obecnie stosowanych lek\u00f3w przeciwdrgawkowych. <\/p>\n

Serdecznie gratulujemy!<\/b><\/p>\n

<\/p>\n

<\/span><\/p>\n<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Z przyjemno\u015bci\u0105 informujemy, \u017ce dwa projekty, w\u00a0kt\u00f3rych bierze udzia\u0142 dr hab. Bernadeta Szewczyk zostan\u0105 sfinansowane w\u00a0programie OPUS 21; jeden wraz z\u00a0 prof. dr hab. Jakubem W\u0142odarczykiem z\u00a0Instytutu Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk pt. “Molekularne mechanizmy rezyliencji zale\u017cne od receptora 5-HT7R w\u00a0chorobach zwi\u0105zanych ze\u00a0stresem” oraz drugi wraz z\u00a0prof. dr hab. Piotrem Wlaziem z\u00a0Uniwersytetu […]<\/p>\n","protected":false},"author":8,"featured_media":1777297403,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-1777123842","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archiwum"],"acf":[],"yoast_head":"\nDwa nowe projekty OPUS 21 - Instytut Farmakologii PAN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/if-pan.edu.pl\/aktualnosci\/archiwum\/dwa-nowe-projekty-opus-21\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dwa nowe projekty OPUS 21\" \/>\n<meta property=\"og:description\" content=\"Z przyjemno\u015bci\u0105 informujemy, \u017ce dwa projekty, w\u00a0kt\u00f3rych bierze udzia\u0142 dr hab. 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