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Department of Pharmacology and Brain Biostructure
Scientific profile
- About department
- Employees
- Laboratories
Research profile
The research interests of the Department of Pharmacology and Brain Biostructure are centered on neurodevelopmental models of schizophrenia. Specifically, our investigations are aimed at identifying the neural substrates underlying behavioral deficits typical for schizophrenia and the discovery of novel potential targets for antipsychotic substances. Another important aspect of our research involves environmental factors (early life stress, enriched environment) that influence brain development and its susceptibility to mental disorders such as anxiety, schizophrenia, cognitive deficits and depression.
Research methods
Behavioral: neurodevelopmental models of schizophrenia, experimental models of stress – maternal separation in the postnatal period, fear conditioning paradigm – the acquisition, retention and extinction of memory traces, sensory motor gating paradigm, novel object recognition test, delayed alternation test, social interaction test, food-preference test, latent inhibition test.
Immunohistochemistry and neuroanatomy: brain tissue staining for identification of specific proteins and their colocalization – microscopic techniques based on light microscopy, fluorescence and laser confocal microscopy, stereological techniques. Stereotactic and iontophoretic techniques of retrograde marker delivery. Methods to assess adult brain neurogenesis.
Biochemistry and molecular biology: protein expression: Western blot, ELISA, protein macroarrays; Real-Time Quantitative Reverse Transcription, chromatin precipitation.
Electrophysiology: in vitro measurements of long-term synaptic potentiation and depression.
Employees
Professor Krystyna Gołembiowska, dr hab.
+48 12 6623211 
nfgolemb@cyf-kr.edu.pl 
room Ojcowska Agnieszka Chocyk, dr hab.
+48 12 6623229
chocyk@if-pan.krakow.pl
room 237 Zofia Rogóż, dr hab.
+48 12 6623279
rogoz@if-pan.krakow.pl
room 103 Wiktor Bilecki, dr
+48 12 6623329
bilecki@if-pan.krakow.pl
room 237 Anna Solarz-Andrzejewska, dr
+48 12 6623246
solarz@if-pan.krakow.pl
room 214 Agnieszka Wawrzczak-Bargieła, dr
+48 12 6623329
bargiela@if-pan.krakow.pl
room 241 Magdalena Tertil, dr
+48 12 3343707
tertil@if-pan.krakow.pl
room Pokój: 1.5 Cephares Weronika Kumorek, inż.
kumorek@if-pan.krakow.pl
room 214 Agnieszka Bysiek, mgr
+48 12 6623303
bysiek@if-pan.krakow.pl
room Ojcowska Beata Zemła
+48 12 6623211
zemla@if-pan.krakow.pl
room 232 Employees
Achievements
- Publications
Molecular and Medical Aspects of Psychedelics
Adam Wojtas, Krystyna Gołembiowska
DOI: 10.3390/ijms25010241
Limbic System Response to Psilocybin and Ketamine Administration in Rats: A Neurochemical and Behavioral Study
Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Marzena Maćkowiak, Krystyna Gołembiowska
DOI: 10.3390/ijms25010100
Hallucinogenic activity, neurotransmitters release, anxiolytic and neurotoxic effects in Rat's brain following repeated administration of novel psychoactive compound 25B-NBOMe
Adam Wojtas, Monika Herian, Marzena Maćkowiak, Anna Solarz, Agnieszka Wawrzczak-Bargiela, Agnieszka Bysiek, Karolina Noworyta, Krystyna Gołembiowska
DOI: 10.1016/j.neuropharm.2023.109713
Limbic System Response to Psilocybin and Ketamine Administration in Rats: A Neurochemical and Behavioral Study
Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Marzena Maćkowiak, Krystyna Gołembiowska
DOI: 10.20944/preprints202309.1649.v1
Effects of early‐life stress and sex on blood–brain barrier permeability and integrity in juvenile and adult rats
Anna Solarz, Iwona Majcher‐Maślanka, Agnieszka Chocyk
DOI: 10.1002/dneu.22846
Tolerance to neurochemical and behavioral effects of the hallucinogen 25I-NBOMe
Monika Herian, Mateusz Skawski, Adam Wojtas, Małgorzata K. Sobocińska, Karolina Noworyta, Krystyna Gołembiowska
DOI: 10.1007/s00213-021-05860-5
Neurochemical and Behavioral Effects of a New Hallucinogenic Compound 25B-NBOMe in Rats
Adam Wojtas, Monika Herian, Mateusz Skawski, Małgorzata Sobocińska, Alejandro González-Marín, Karolina Noworyta-Sokołowska, Krystyna Gołembiowska
DOI: 10.1007/s12640-020-00297-8
A Search for Biomarkers of Early-life Stress-related Psychopathology: Focus on 70-kDa Heat Shock Proteins.
DOI: 10.1016/j.neuroscience.2021.02.026
1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia.
DOI: 10.1007/s43440-020-00209-9
Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission
Monika Herian, Adam Wojtas, Małgorzata Katarzyna Sobocińska, Mateusz Skawski, Alejandro González-Marín, Krystyna Gołembiowska
DOI: 10.1007/s43440-020-00181-4
