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Department of Pharmacology and Brain Biostructure
Scientific profile
- About department
- Employees
- Laboratories
Research profile
The research interests of the Department of Pharmacology and Brain Biostructure are centered on neurodevelopmental models of schizophrenia. Specifically, our investigations are aimed at identifying the neural substrates underlying behavioral deficits typical for schizophrenia and the discovery of novel potential targets for antipsychotic substances. Another important aspect of our research involves environmental factors (early life stress, enriched environment) that influence brain development and its susceptibility to mental disorders such as anxiety, schizophrenia, cognitive deficits and depression.
Research methods
Behavioral: neurodevelopmental models of schizophrenia, experimental models of stress – maternal separation in the postnatal period, fear conditioning paradigm – the acquisition, retention and extinction of memory traces, sensory motor gating paradigm, novel object recognition test, delayed alternation test, social interaction test, food-preference test, latent inhibition test.
Immunohistochemistry and neuroanatomy: brain tissue staining for identification of specific proteins and their colocalization – microscopic techniques based on light microscopy, fluorescence and laser confocal microscopy, stereological techniques. Stereotactic and iontophoretic techniques of retrograde marker delivery. Methods to assess adult brain neurogenesis.
Biochemistry and molecular biology: protein expression: Western blot, ELISA, protein macroarrays; Real-Time Quantitative Reverse Transcription, chromatin precipitation.
Electrophysiology: in vitro measurements of long-term synaptic potentiation and depression.
Employees
Professor Krystyna Gołembiowska, dr hab.
+48 12 6623211 
nfgolemb@cyf-kr.edu.pl 
room Ojcowska Agnieszka Chocyk, dr hab.
+48 12 6623229
chocyk@if-pan.krakow.pl
room 237 Zofia Rogóż, dr hab.
+48 12 6623279
rogoz@if-pan.krakow.pl
room 103 Wiktor Bilecki, dr
+48 12 6623329
bilecki@if-pan.krakow.pl
room 237 Anna Solarz-Andrzejewska, dr
+48 12 6623246
solarz@if-pan.krakow.pl
room 214 Agnieszka Wawrzczak-Bargieła, dr
+48 12 6623329
bargiela@if-pan.krakow.pl
room 241 Magdalena Tertil, dr
+48 12 3343707
tertil@if-pan.krakow.pl
room Pokój: 1.5 Cephares Weronika Kumorek, inż.
kumorek@if-pan.krakow.pl
room 214 Agnieszka Bysiek, mgr
+48 12 6623303
bysiek@if-pan.krakow.pl
room Ojcowska Beata Zemła
+48 12 6623211
zemla@if-pan.krakow.pl
room 232 Employees
Achievements
- Publications
Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats
Chocyk, A., Dudys, D., Przyborowska, A., Majcher, I., Maćkowiak, M., Weogonekdzony, K.
DOI: 10.1016/j.neuroscience.2010.11.037
The impact of maternal separation on the number of tyrosine hydroxylase-expressing midbrain neurons during different stages of ontogenesis
Chocyk, A., Przyborowska, A., Dudys, D., Majcher, I., Maćkowiak, M., Wedzony, K.
DOI: 10.1016/j.neuroscience.2011.03.008
Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats
Chocyk, A., Dudys, D., Przyborowska, A., Maćkowiak, M., Wȩdzony, K.
DOI: 10.1016/S1734-1140(10)70385-6
Cannabinoid CB1 receptors in rat medial prefrontal cortex are colocalized with calbindin- but not parvalbumin- and calretinin-positive GABA-ergic neurons
Wȩdzony, K., Chocyk, A.
DOI: 10.1016/S1734-1140(09)70161-6
Repeated risperidone treatment increases the expression of NCAM and PSA-NCAM protein in the rat medial prefrontal cortex
Maćkowiak, M., Dudys, D., Chocyk, A., Wedzony, K.
DOI: 10.1016/j.euroneuro.2008.10.001
Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - A biochemical and behavioral study
Starowicz, K., Mousa, S.A., Obara, I., Chocyk, A., Przewłocki, R., Wȩdzony, K., Machelska, H., Przewłocka, B.
DOI: 10.1016/S1734-1140(09)70171-9
Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning
Maćkowiak, M., Chocyk, A., Dudys, D., Wedzony, K.
DOI: 10.1016/j.neuroscience.2008.11.037
Detrimental effect of postnatal blockade of N-methyl-D-aspartate receptors on sensorimotor gating is reversed by neuroleptic drugs
Wedzony, K., Fijał, K., Maćkowiak, M., Chocyk, A.
DOI:
A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices - Immunohistochemical studies
Wȩdzony, K., Chocyk, A., Maćkowiak, M.
DOI:
Dopamine D1-like receptors agonist SKF 38393 increases cFos expression in the paraventricular nucleus of the hypothalamus - Impact of acute and chronic cocaine
Chocyk, A., Czyrak, A., Wȩdzony, K.
DOI:
